9HI7

Structure of MC.7.G5 T cell receptor in complex with MR1 R9H

Summary for 9HI7

• Entry DOI: 10.2210/pdb9hi7/pdb
• Descriptor: Major histocompatibility complex class I-related gene protein, Beta-2-microglobulin, T cell receptor alpha chain MC.7.G5, ... (5 entities in total)
• Functional Keywords: tcr, mr1, mait, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 193019.33

Authors

Karuppiah, V. (deposition date: 2024-11-24, release date: 2025-04-23)

Primary citation

Suckling, R.J.,Pamukcu, C.,Simmons, R.A.,Fonseca, D.,Grant, E.,Harrison, R.,Shaikh, S.A.,Khanolkar, R.C.,Ghadbane, H.,Creese, A.,Hock, M.,Gligoris, T.G.,Lepore, M.,Karuppiah, V.,Salio, M.
Molecular basis underpinning MR1 allomorph recognition by an MR1-restricted T cell receptor.
Front Immunol, 16:1547664-1547664, 2025

PubMed Abstract: The MHC-class-I-related molecule MR1 presents small metabolites of microbial and self-origin to T cells bearing semi-invariant or variant T cell receptors. One such T cell receptor, MC.7.G5, was previously shown to confer broad MR1-restricted reactivity to tumor cells but not normal cells, sparking interest in the development of non-MHC-restricted immunotherapy approaches.

PubMed: 40207221
DOI: 10.3389/fimmu.2025.1547664

Experimental method

X-RAY DIFFRACTION (2.81 Å)