9HGR
In vitro grown WT Alpha-Synuclein Fibrils
Summary for 9HGR
| Entry DOI | 10.2210/pdb9hgr/pdb |
| Related | 9HGS |
| EMDB information | 52165 |
| Descriptor | Alpha-synuclein (1 entity in total) |
| Functional Keywords | alpha-synuclein, g14r mutation, fibrils, cryo-em, protein aggregation, amyloid structure, protein fibril |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 28952.22 |
| Authors | Sicking, K.,Al-Azzani, M.,Outeiro, T.F.,Fernandez-Busnadiego, R. (deposition date: 2024-11-20, release date: 2025-01-29, Last modification date: 2025-10-08) |
| Primary citation | Brucke, C.,Al-Azzani, M.,Ramalingam, N.,Ramon, M.,Sousa, R.L.,Buratti, F.,Zech, M.,Sicking, K.,Amaral, L.,Gelpi, E.,Chandran, A.,Agarwal, A.,Chaves, S.R.,Fernandez, C.O.,Dettmer, U.,Lautenschlager, J.,Zweckstetter, M.,Busnadiego, R.F.,Zimprich, A.,Outeiro, T.F. A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features. Mol Neurodegener, 20:98-98, 2025 Cited by PubMed Abstract: Parkinson's disease (PD) affects millions of people worldwide, but only 5-10% of patients suffer from a monogenic forms of the disease with Mendelian inheritance. SNCA, the gene encoding for the protein alpha-synuclein (aSyn), was the first to be associated with familial forms of PD and, since then, several missense variants and multiplications of the gene have been established as rare causes of autosomal dominant forms of PD. In this study, we report the identification of a novel SNCA mutation in a patient that presented with a complex neurogenerative disorder, and unconventional neuropathological findings. We also performed in depth molecular studies of the effects of the novel aSyn mutation. PubMed: 41013605DOI: 10.1186/s13024-025-00889-y PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.7 Å) |
Structure validation
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