9HGS
In vitro grown G14R Alpha-Synuclein Fibrils
Summary for 9HGS
Entry DOI | 10.2210/pdb9hgs/pdb |
EMDB information | 52166 |
Descriptor | Alpha-synuclein (1 entity in total) |
Functional Keywords | alpha-synuclein, g14r mutation, fibrils, cryo-em, protein aggregation, amyloid structure, protein fibril |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 14576.25 |
Authors | |
Primary citation | Brucke, C.,Al-Azzani, M.,Ramalingam, N.,Ramon, M.,Sousa, R.L.,Buratti, F.,Zech, M.,Sicking, K.,Amaral, L.,Gelpi, E.,Chandran, A.,Agarwal, A.,Chaves, S.R.,Fernandez, C.O.,Dettmer, U.,Lautenschlager, J.,Zweckstetter, M.,Busnadiego, R.F.,Zimprich, A.,Outeiro, T.F. A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features. Medrxiv, 2024 Cited by PubMed Abstract: Parkinson's disease (PD) affects millions of people worldwide, but only 5-10% of patients suffer from a monogenic form of the disease with Mendelian inheritance. the gene encoding for the protein alpha-synuclein (aSyn), was the first to be associated with familial forms of PD and, since then, several missense variants and multiplications of the gene have been established as rare causes of autosomal dominant forms of PD. PubMed: 39399048DOI: 10.1101/2024.09.23.24313864 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3 Å) |
Structure validation
Download full validation report
