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9HGS

In vitro grown G14R Alpha-Synuclein Fibrils

Summary for 9HGS
Entry DOI10.2210/pdb9hgs/pdb
EMDB information52166
DescriptorAlpha-synuclein (1 entity in total)
Functional Keywordsalpha-synuclein, g14r mutation, fibrils, cryo-em, protein aggregation, amyloid structure, protein fibril
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight14576.25
Authors
Sicking, K.,Fernandez-Busnadiego, R. (deposition date: 2024-11-20, release date: 2025-01-29)
Primary citationBrucke, C.,Al-Azzani, M.,Ramalingam, N.,Ramon, M.,Sousa, R.L.,Buratti, F.,Zech, M.,Sicking, K.,Amaral, L.,Gelpi, E.,Chandran, A.,Agarwal, A.,Chaves, S.R.,Fernandez, C.O.,Dettmer, U.,Lautenschlager, J.,Zweckstetter, M.,Busnadiego, R.F.,Zimprich, A.,Outeiro, T.F.
A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features.
Medrxiv, 2024
Cited by
PubMed Abstract: Parkinson's disease (PD) affects millions of people worldwide, but only 5-10% of patients suffer from a monogenic form of the disease with Mendelian inheritance. the gene encoding for the protein alpha-synuclein (aSyn), was the first to be associated with familial forms of PD and, since then, several missense variants and multiplications of the gene have been established as rare causes of autosomal dominant forms of PD.
PubMed: 39399048
DOI: 10.1101/2024.09.23.24313864
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3 Å)
Structure validation

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