9HCO

Outward-open structure of human serotonin transporter bound to vilazodone

Summary for 9HCO

• Entry DOI: 10.2210/pdb9hco/pdb
• EMDB information: 52050
• Descriptor: Sodium-dependent serotonin transporter, 15B8 Fab heavy chain, 15B8 Fab light chain, ... (7 entities in total)
• Functional Keywords: monoamine transporter, leut fold, antidepressant binding, inhibitor complex, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 124714.90

Authors

Kalenderoglou, I.E.,Tillmann, P.,Loland, C.J. (deposition date: 2024-11-11, release date: 2025-09-17)

• Primary citation: Kalenderoglou, I.E.,Nygaard, A.,Vogt, C.D.,Turaev, A.,Pape, T.,Adams, N.,Newman, A.H.,Loland, C.J.; Structural basis of serotonin reuptake inhibition by a dual mode orthosteric/allosteric antidepressant; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.78 Å)