9H59

Cryo-EM structure of DDB1-CRBN in complex with NK7-902 and NEK7

This is a non-PDB format compatible entry.

Summary for 9H59

• Entry DOI: 10.2210/pdb9h59/pdb
• EMDB information: 51881
• Descriptor: DNA damage-binding protein 1, Serine/threonine-protein kinase Nek7, Protein cereblon, ... (4 entities in total)
• Functional Keywords: crbn, ddb1, nek7, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 214778.83

Authors

Khoshouei, M.,Schroeder, M. (deposition date: 2024-10-22, release date: 2025-06-25, Last modification date: 2026-08-05)

• Primary citation: Sylvain, A.,Stoehr, N.,Ma, F.,Cernijenko, A.,Schroder, M.,Khoshouei, M.,Vogelsanger, M.,Schoenboerner, M.,Burke, A.,Pasupuleti, R.,Solomon, J.,Paulk, J.,Xu, L.,Dawson, J.,Begue, D.,Lefeuvre, P.,Ahrne, E.,Hofmann, A.,Dickson, C.J.,Arabin, P.,Zimmerlin, A.,Kiffe, M.,Froehlicher, M.,Boersig, T.,Elhajouji, A.,Brichet, M.,Menon, S.,Liu, S.,Mueller, M.,Wartchow, C.,Lin, J.,Cardona Gloria, Y.,Dickhofer, S.,Weber, A.N.R.,Welzel, T.,Kuemmerle-Deschner, J.,Farady, C.J.,Pulz, R.,Bornancin, F.,Buckley, D.L.,Bassi, Z.I.; A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation; Biorxiv, 2024; DOI: 10.1101/2024.11.06.622079

Experimental method

ELECTRON MICROSCOPY (3.4 Å)