9H31

T2R-TTL-PROTAC4 complex

これはPDB形式変換不可エントリーです。

9H31 の概要

• エントリーDOI: 10.2210/pdb9h31/pdb
• 関連するPDBエントリー: 9H30
• 分子名称: Tubulin alpha-1B chain, N-[5-(1-{2-[4-({[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl]oxy}carbonyl)phenyl]ethyl}-1H-1,2,3-triazol-4-yl)pentanoyl]-3-methyl-D-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• 機能のキーワード: cell cycle, tubulin fold, cytoskeleton, microtubule
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265823.29

構造登録者

Maiocchi, A.,Abel, A.-C.,Steinmetz, M.O.,Passarella, D.,Prota, A.E. (登録日: 2024-10-15, 公開日: 2025-10-29)

• 主引用文献: Maiocchi, A.,Abel, A.-C.,Basellini, M.,Perez Pena, H.,Boiarska, Z.,Ferrandi, E.,Kozicka, Z.,Fasano, V.,Pieraccini, S.,Cappelletti, G.,Steinmetz, M.O.,Prota, A.E.,Passarella, D.; Effective tubulin degradation by rationally designed Proteolysis Targeting Chimeras; To Be Published,

実験手法

X-RAY DIFFRACTION (2.2 Å)