9GWP

Human PPAR-gamma ligand binding domain in complex with MRL-871 with two distinct binding modes

Summary for 9GWP

• Entry DOI: 10.2210/pdb9gwp/pdb
• Descriptor: Peroxisome proliferator-activated receptor gamma, 4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-1H-indazol-3-yl}benzoic acid (3 entities in total)
• Functional Keywords: ppar, ppar gamma, pparg, peroxisome proliferator-activated receptor gamma, nuclear receptor, transcription factor, partial agonist, agonist, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 63710.56

Authors

Oerlemans, G.J.M.,Koops, A.A.,Brunsveld, L. (deposition date: 2024-09-27, release date: 2025-10-08)

• Primary citation: Koops, A.A.,Oerlemans, G.J.M.,Brunsveld, L.; Development and characterization of novel indazole-based PPAR-gamma partial agonists; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.55 Å)