9GWP
Human PPAR-gamma ligand binding domain in complex with MRL-871 with two distinct binding modes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Peroxisome proliferator-activated receptor gamma | polymer | 275 | 31410.5 | 2 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (human) | PPAR-gamma,Nuclear receptor subfamily 1 group C member 3 |
| 2 | C, D (A, B) | 4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-1H-indazol-3-yl}benzoic acid | non-polymer | 444.8 | 2 | Chemie (4F1) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A, B: 235 - 505 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Gly 231 | - | expression tag |
| Ser 232 | - | expression tag |
| His 233 | - | expression tag |
| Met 234 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62821.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 889.6 | |
| All* | Total formula weight | 63710.6 |
