9GV9

Structure of Heparinase I from Bacteroides eggerthii in complex with calcium cofactor and delta-UA(1-4)Glc 3, 6, N-Sulphated disaccharide

Summary for 9GV9

• Entry DOI: 10.2210/pdb9gv9/pdb
• Descriptor: Heparin lyase I, 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ACETATE ION, ... (6 entities in total)
• Functional Keywords: heparin, heparan sulphate, heparinase, lyase, heparitinase
• Biological source: Bacteroides eggerthii
• Total number of polymer chains: 2
• Total formula weight: 90178.96

Authors

Mycroft-West, C.,Wu, L. (deposition date: 2024-09-23, release date: 2025-10-08)

• Primary citation: Kandola, T.K.,Mycroft-West, C.,Andrade De Lima, M.L.,Turner, A.,Gardini, C.,Urso, E.,Miller, G.J.,Bisio, A.,Yates, E.A.,Guerrini, M.,Wu, L.,Skidmore, M.A.; Bacteroides eggerthii heparin lyase I liberates the rare delta-GlcA(alpha1->4)Glc3,6,N-sulphated disaccharide motif contained within the pentasaccharide of the clinical anticoagulant fondaparinux sodium; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.715 Å)