9GP7

Cryo EM structure of the E307T mutant of the human P2X4 receptor in complex with the anthraquinone derivative PSB-0704

This is a non-PDB format compatible entry.

Summary for 9GP7

• Entry DOI: 10.2210/pdb9gp7/pdb
• EMDB information: 51502
• Descriptor: P2X purinoceptor 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 1-azanyl-4-[(3-carboxy-4-phenylazanyl-phenyl)amino]-9,10-bis(oxidanylidene)anthracene-2-carboxylic acid, ... (4 entities in total)
• Functional Keywords: p2x4, receptor, inhibitor, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 142326.79

Authors

Nagel, J.,Vaaen, V.,Torp, J.,Geyer, M.,Claff, T.,Hagelueken, G.,Mueller, C.E. (deposition date: 2024-09-06, release date: 2025-11-26)

• Primary citation: Nagel, J.,Weinhausen, S.,Namasivayam, V.,Baqi, Y.,Al Musawi, H.A.M.,Abdelrahman, A.,Vaassen, V.,Schlegel, J.,Taplick, L.,Torp, J.,Kubicek, J.,Maertens, B.,Geyer, M.,Claff, T.,Hagelueken, G.,Mueller, C.E.; Discovery of an allosteric P2X receptor binding site for anthraquinones by a chimeric approach combined with computational studies, bump-and-hole mutagenesis, and cryo-electron microscopy; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.35 Å)