9GL9

Wild-type EGFR bound with STX-721

This is a non-PDB format compatible entry.

Summary for 9GL9

• Entry DOI: 10.2210/pdb9gl9/pdb
• Descriptor: Epidermal growth factor receptor, CHLORIDE ION, (2R,3S)-3-[(3-chloranyl-2-methoxy-phenyl)amino]-2-[3-[2-[(2R)-1-[(E)-4-(dimethylamino)but-2-enoyl]-2-methyl-pyrrolidin-2-yl]ethynyl]pyridin-4-yl]-1,2,3,5,6,7-hexahydropyrrolo[3,2-c]pyridin-4-one, ... (4 entities in total)
• Functional Keywords: kinase, inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 38223.49

Authors

Hilbert, B.J.,Brooijmans, N.,Milgram, B.C.,Pagliarini, R.A. (deposition date: 2024-08-27, release date: 2025-05-14)

• Primary citation: Milgram, B.C.,Pagliarini, R.A.,Borrelli, D.R.,OHearn, E.,Huff, M.R.,Ladd, B.,Brooijmans, N.,Henderson, J.A.,Hilbert, B.J.,Wang, W.,Ito, T.,Jonsson, P.,Jackson, E.L.,Guzman-Perez, A.; Wild-type EGFR bound with STX-721; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.147 Å)