9GHT

Crystal Structure of EGFR-WT in Complex with BI-4020

Summary for 9GHT

• Entry DOI: 10.2210/pdb9ght/pdb
• Descriptor: Epidermal growth factor receptor, (20R)-10,15,20-trimethyl-2-[(4-methylpiperazin-1-yl)methyl]-18,19,20,21-tetrahydro-15H,17H-12,8-(metheno)pyrazolo[3',4':2,3][1,5,10,12]oxatriazacycloheptadecino[12,11-a]benzimidazol-7(6H)-one (3 entities in total)
• Functional Keywords: egfr, wt, exon20, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 38418.43

Authors

Niggenaber, J.,Mueller, M.P.,Rauh, D. (deposition date: 2024-08-16, release date: 2026-03-04)

• Primary citation: Grabe, T.,Jeyakumar, K.,Niggenaber, J.,Grabe, B.,Koska, S.,Zischinsky, M.,Unger, A.,Weisner, J.,Arndt, A.,Mueller, M.P.,Rauh, D.; Selective Targeting of EGFR-Exon20 Insertion Mutations in Non-Small Cell Lung Cancer with Nazartinib and BI-4020 Inspired Hybrid Inhibitors; to be published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)