9GHT
Crystal Structure of EGFR-WT in Complex with BI-4020
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 333 | 37875.8 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | (20R)-10,15,20-trimethyl-2-[(4-methylpiperazin-1-yl)methyl]-18,19,20,21-tetrahydro-15H,17H-12,8-(metheno)pyrazolo[3',4':2,3][1,5,10,12]oxatriazacycloheptadecino[12,11-a]benzimidazol-7(6H)-one | non-polymer | 542.7 | 1 | Chemie (XA4) | |||
| 3 | C (A) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 690 | - | expression tag |
| Ser 691 | - | expression tag |
| His 692 | - | expression tag |
| Met 693 | - | expression tag |
| Ala 694 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37875.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 542.7 | |
| All* | Total formula weight | 38418.4 |
