9GGC

Structure of the G848S mutant of human mitochondrial DNA polymerase gamma

Summary for 9GGC

• Entry DOI: 10.2210/pdb9ggc/pdb
• Related: 9GGB 9GGD 9GGE 9GGF
• EMDB information: 51326 51327 51328 51329 51330
• Descriptor: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, DNA (primer strand), ... (6 entities in total)
• Functional Keywords: mitochondrial dna polymerase, activator, transferase/dna, transferase-dna complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 264969.06

Authors

Valenzuela, S.,Falkenberg, M. (deposition date: 2024-08-13, release date: 2025-04-16)

• Primary citation: Valenzuela, S.,Xuefeng, Z.,Macao, M.,Stamgren, M.,Geukens, C.,Charifson, P.S.,Kern, G.,Hoberg, E.,Jenninger, L.,Gruszczyk, A.V.,Lee, S.,Johansson, K.A.S.,Miralles Fuste, J.,Shi, Y.,Kerns, S.J.,Arabanian, L.,Martinez Botella, G.,Green, J.,Griffin, A.,Pardo Hernandez, C.,Keating, T.A.,Larsson, N.G.,Phan, C.,Posse, V.,Jones, J.E.,Xie, X.,Giroux, S.,Gustafsson, C.M.,Falkenberg, M.; Small molecules restore mutant mitochondrial DNA polymerase activity; To Be Published, 2025; DOI: 10.1038/s41586-025-08856-9

Experimental method

ELECTRON MICROSCOPY (2.39 Å)