9GEW

Crystal structure of CREBBP bromodomain in complex with (R,E)-6-(5-(6-methoxy-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)pent-1-en-1-yl)-4-methyl-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one

This is a non-PDB format compatible entry.

Summary for 9GEW

• Entry DOI: 10.2210/pdb9gew/pdb
• Related: 9GEJ 9GET 9GEU
• Descriptor: CREBBP, (4~{R})-6-[(~{E})-5-(6-methoxy-2,3-dihydro-1,4-benzoxazin-4-yl)pent-1-enyl]-4-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one, (R,R)-2,3-BUTANEDIOL, ... (4 entities in total)
• Functional Keywords: bromodomain, crebbp, protein-inhibitor complex, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 14901.22

Authors

Amann, M.,Boyd, A.,Einsle, O.,Moroglu, M.,Conway, S. (deposition date: 2024-08-07, release date: 2025-08-20)

• Primary citation: Amann, M.,Boyd, A.,Einsle, O.,Moroglu, M.,Conway, S.; Crystal structure of CREBBP bromodomain in complex with (R,E)-6-(5-(6-methoxy-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)pent-1-en-1-yl)-4-methyl-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.47 Å)