9FRS

Human PARP10 ART domain bound to a phthalazinone-based inhibitor

This is a non-PDB format compatible entry.

Summary for 9FRS

• Entry DOI: 10.2210/pdb9frs/pdb
• Related: 9FRP
• Descriptor: Protein mono-ADP-ribosyltransferase PARP10, 4-[[4-fluoranyl-3-[[(5~{R})-5-methyl-3-(1,3-thiazol-2-yl)-6,8-dihydro-5~{H}-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]carbonyl]phenyl]methyl]-2~{H}-phthalazin-1-one, ACETATE ION, ... (5 entities in total)
• Functional Keywords: mono-adp-ribosyltransferase, kinase activity regulator, nuclear protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 46123.70

Authors

Moche, M.,Upadhyaya, K.,Cohen, M.S.,Schuler, H. (deposition date: 2024-06-19, release date: 2026-01-14)

• Primary citation: Moche, M.,Upadhyaya, K.,Cohen, M.S.,Schuler, H.; Human PARP10 ART domain bound to a phthalazinone-based inhibitor; To be published,

Experimental method

X-RAY DIFFRACTION (2.02 Å)