9FRS
Human PARP10 ART domain bound to a phthalazinone-based inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protein mono-ADP-ribosyltransferase PARP10 | polymer | 198 | 22483.5 | 2 | UniProt (Q53GL7) Pfam (PF00644) | Homo sapiens (human) | ADP-ribosyltransferase diphtheria toxin-like 10,ARTD10,Poly [ADP-ribose] polymerase 10,PARP-10 |
| 2 | C, F (A, B) | 4-[[4-fluoranyl-3-[[(5~{R})-5-methyl-3-(1,3-thiazol-2-yl)-6,8-dihydro-5~{H}-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]carbonyl]phenyl]methyl]-2~{H}-phthalazin-1-one | non-polymer | 501.5 | 2 | Chemie (A1IFC) | |||
| 3 | D, G (A, B) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 4 | E (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 248 | Chemie (HOH) |
Sequence modifications
A, B: 814 - 1006 (UniProt: Q53GL7)
| PDB | External Database | Details |
|---|---|---|
| Met 813 | - | initiating methionine |
| Lys 922 | Arg 922 | conflict |
| Ala 1007 | - | expression tag |
| His 1008 | - | expression tag |
| His 1009 | - | expression tag |
| His 1010 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44967.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1156.6 | |
| All* | Total formula weight | 46123.7 |
