9FE1

Cryo-EM structure of the ternary DARPin NY_1/HLA-A0201/NY-ESO1 complex.

Summary for 9FE1

• Entry DOI: 10.2210/pdb9fe1/pdb
• Related: 9EPA
• EMDB information: 50336
• Descriptor: MHC class I antigen, Beta-2-microglobulin, Cancer/testis antigen 1, ... (4 entities in total)
• Functional Keywords: darpin targeting mhc molecules in complex with tumor-associated peptide antigens, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 65106.96

Authors

Schulte, T.,Wallden, K.,Carroni, M.,Sandalova, T.,Walser, M.,Mueller, S.,Venetz, N.,Achour, A. (deposition date: 2024-05-17, release date: 2025-05-28)

• Primary citation: Venetz, N.,Schulte, T.,Mueller, S.,Wallden, K.,Fischer, S.,Kadri, N.,Paladino, M.,Pina, N.,Radom, F.,Villemagne, D.,Bruckmaier, S.,Cornelius, A.,Hospodarsch, T.,Sun, R.,Chambers, B.J.,Carroni, M.,Levitsky, V.,Sandalova, T.,Walser, M.,Achour, A.; Development of highly specific and potent HLA/peptide-targeting DARPin T cell engagers; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.1 Å)