9FCJ

USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (ordered subset, focused refinement)

Summary for 9FCJ

• Entry DOI: 10.2210/pdb9fcj/pdb
• Related: 7ZH3 7ZH4 9FCI
• EMDB information: 50317
• Descriptor: Polyubiquitin-C, Ubiquitin carboxyl-terminal hydrolase 1, ZINC ION, ... (5 entities in total)
• Functional Keywords: inhibitor, deubiquitinase, complex, enzyme-substrate, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 97715.28

Authors

Rennie, M.L.,Gundogdu, M.,Walden, H. (deposition date: 2024-05-15, release date: 2024-09-04)

• Primary citation: Rennie, M.L.,Gundogdu, M.,Arkinson, C.,Liness, S.,Frame, S.,Walden, H.; Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.; J.Med.Chem., 2024; PubMed: 39190802; DOI: 10.1021/acs.jmedchem.4c01184

Experimental method

ELECTRON MICROSCOPY (2.7 Å)