9F42
cryo-EM structure of LST2 TOS peptide bound to human mTOR complex 1, focused on RAPTOR
Summary for 9F42
| Entry DOI | 10.2210/pdb9f42/pdb |
| EMDB information | 50181 |
| Descriptor | Regulatory-associated protein of mTOR, Lateral signaling target protein 2 homolog (2 entities in total) |
| Functional Keywords | mtor, mtorc1, lst2, zfyve28, egfr, tos, signaling protein |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 154425.39 |
| Authors | Craigie, L.M.,Maier, T. (deposition date: 2024-04-26, release date: 2024-08-14, Last modification date: 2024-08-28) |
| Primary citation | Battaglioni, S.,Craigie, L.M.,Filippini, S.,Maier, T.,Hall, M.N. mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR. Proc.Natl.Acad.Sci.USA, 121:e2405959121-e2405959121, 2024 Cited by PubMed: 39141345DOI: 10.1073/pnas.2405959121 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.27 Å) |
Structure validation
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