9F1M
First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 45
This is a non-PDB format compatible entry.
Summary for 9F1M
Entry DOI | 10.2210/pdb9f1m/pdb |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, SODIUM ION, ... (5 entities in total) |
Functional Keywords | bromodomain, epigenetic drugs, inhibitor, protacs, vhl, gene regulation |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 65290.72 |
Authors | Balourdas, D.I.,Edmonds, A.K.,Marsh, G.P.,Maple, H.J.,Spencer, J.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2024-04-19, release date: 2024-09-11) |
Primary citation | Balourdas, D.I.,Edmonds, A.K.,Marsh, G.P.,Maple, H.J.,Spencer, J.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 45 to be published, |
Experimental method | X-RAY DIFFRACTION (1.90001265923 Å) |
Structure validation
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