9EZH

Structure of single-domain antibody VHH_h4 in complex with human Vsig4

Summary for 9EZH

• Entry DOI: 10.2210/pdb9ezh/pdb
• Descriptor: V-set and immunoglobulin domain-containing protein 4, VHH_h4, GLYCEROL, ... (4 entities in total)
• Functional Keywords: nanobody, mutations, cdr2, cdr3, hvsig4, b7 family, immune regulatory proteins, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 26915.95

Authors

Vizarraga, D.,Cianferoni, D.,Delgado, J.,van der Kant, R.,Garcia, T.,Maragkou, K.,Zhang, Z.,Dewilde, M.,Schymkowitz, J.,Rousseau, F.,Serrano, L. (deposition date: 2024-04-12, release date: 2025-10-29)

• Primary citation: van der Kant, R.,Zhang, Z.,Markovic, I.,Vizarraga, D.,Garcia, T.,Maragkou, K.,Delgado, J.,Cianferoni, D.,Orlando, G.,Carolis, C.,Savvides, S.,N.Volkov, A.,Dewilde, M.,Schymkowitz, J.,Serrano, L.,Rousseau, F.; In silico design of stable single-domain antibodies against multiple targets.; To be published,

Experimental method

X-RAY DIFFRACTION (1.94 Å)