9EXX

Crystal structure of the PWWP1 domain of NSD2 bound by compound 18.

This is a non-PDB format compatible entry.

Summary for 9EXX

• Entry DOI: 10.2210/pdb9exx/pdb
• Descriptor: Histone-lysine N-methyltransferase NSD2, 1,2-ETHANEDIOL, ETHANOL, ... (5 entities in total)
• Functional Keywords: methyl transferase, inhibitor, cancer drug discovery, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 40219.86

Authors

Collie, G.W. (deposition date: 2024-04-09, release date: 2024-05-29)

• Primary citation: Carlino, L.,Astles, P.C.,Ackroyd, B.,Ahmed, A.,Chan, C.,Collie, G.W.,Dale, I.L.,O'Donovan, D.H.,Fawcett, C.,di Fruscia, P.,Gohlke, A.,Guo, X.,Hao-Ru Hsu, J.,Kaplan, B.,Milbradt, A.G.,Northall, S.,Petrovic, D.,Rivers, E.L.,Underwood, E.,Webb, A.; Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches.; J.Med.Chem., 2024; PubMed: 38748070; DOI: 10.1021/acs.jmedchem.4c00215

Experimental method

X-RAY DIFFRACTION (1.943 Å)