9EXX
Crystal structure of the PWWP1 domain of NSD2 bound by compound 18.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-lysine N-methyltransferase NSD2 | polymer | 174 | 19478.2 | 2 | UniProt (O96028) Pfam (PF00855) | Homo sapiens (human) | Multiple myeloma SET domain-containing protein,MMSET,Nuclear SET domain-containing protein 2,Protein trithorax-5,Wolf-Hirschhorn syndrome candidate 1 protein |
| 2 | C, F, G, H (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 3 | D, I, J (A, B) | ETHANOL | non-polymer | 46.1 | 3 | Chemie (EOH) | |||
| 4 | E, K (A, B) | 4-methyl-3-[1-methyl-5-(3-oxidanylidene-4~{H}-1,4-benzoxazin-7-yl)imidazol-4-yl]-~{N}-phenyl-benzamide | non-polymer | 438.5 | 2 | Chemie (A1H7Y) | |||
| 5 | L, M (A, B) | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
A, B: 208 - 368 (UniProt: O96028)
| PDB | External Database | Details |
|---|---|---|
| Met 204 | - | initiating methionine |
| Gly 205 | - | expression tag |
| Gly 206 | - | expression tag |
| Gly 207 | - | expression tag |
| Gly 369 | - | expression tag |
| Gly 370 | - | expression tag |
| Gly 371 | - | expression tag |
| Glu 372 | - | expression tag |
| Asn 373 | - | expression tag |
| Leu 374 | - | expression tag |
| Tyr 375 | - | expression tag |
| Phe 376 | - | expression tag |
| Gln 377 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38956.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1263.4 | |
| All* | Total formula weight | 40219.9 |
