9EWL

The sTeLIC pentameric Ligand-Gated Ion Channel (wild-type) in complex with 4-bromoamphetamine

Summary for 9EWL

Entry DOI	10.2210/pdb9ewl/pdb
Descriptor	Cys-loop ligand-gated ion channel, nonyl beta-D-glucopyranoside, (2S)-1-(4-bromophenyl)propan-2-amine, ... (4 entities in total)
Functional Keywords	ion channel, membrane protein
Biological source	endosymbiont of Tevnia jerichonana (vent Tica)
Total number of polymer chains	5
Total formula weight	188850.19
Authors	Fourati, Z.,Delarue, M. (deposition date: 2024-04-04, release date: 2025-03-26)
Primary citation	Karlsson, E.,Anden, O.,Fan, C.,Fourati, Z.,Haouz, A.,Zhuang, Y.,Howard, R.J.,Delarue, M.,Lindahl, E. Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel. Br.J.Pharmacol., 2025 Cited by PubMed Abstract: Allosteric modulation of pentameric ligand-gated ion channels (pLGICs) are critical for the action of neurotransmitters and many psychoactive drugs. However, details of their modulatory mechanisms remain unclear, especially beyond the orthosteric neurotransmitter-binding sites. The recently reported prokaryotic symbiont of Tevnia jerichonana ligand-gated ion channel (sTeLIC), a pH-gated homologue of eukaryotic receptors in the pLGIC family, is thought to be modulated by aromatic compounds via a relatively uncharacterised modulatory site in the extracellular vestibule. PubMed: 40065647 DOI: 10.1111/bph.70011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation