9EWL

The sTeLIC pentameric Ligand-Gated Ion Channel (wild-type) in complex with 4-bromoamphetamine

This is a non-PDB format compatible entry.

Summary for 9EWL

• Entry DOI: 10.2210/pdb9ewl/pdb
• Descriptor: Cys-loop ligand-gated ion channel, nonyl beta-D-glucopyranoside, (2S)-1-(4-bromophenyl)propan-2-amine, ... (4 entities in total)
• Functional Keywords: ion channel, membrane protein
• Biological source: endosymbiont of Tevnia jerichonana (vent Tica)
• Total number of polymer chains: 5
• Total formula weight: 188850.19

Authors

Fourati, Z.,Delarue, M. (deposition date: 2024-04-04, release date: 2025-03-26, Last modification date: 2025-05-28)

Primary citation

Karlsson, E.,Anden, O.,Fan, C.,Fourati, Z.,Haouz, A.,Zhuang, Y.,Howard, R.J.,Delarue, M.,Lindahl, E.
Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel.
Br.J.Pharmacol., 182:2790-2802, 2025

PubMed Abstract: Allosteric modulation of pentameric ligand-gated ion channels (pLGICs) are critical for the action of neurotransmitters and many psychoactive drugs. However, details of their modulatory mechanisms remain unclear, especially beyond the orthosteric neurotransmitter-binding sites. The recently reported prokaryotic symbiont of Tevnia jerichonana ligand-gated ion channel (sTeLIC), a pH-gated homologue of eukaryotic receptors in the pLGIC family, is thought to be modulated by aromatic compounds via a relatively uncharacterised modulatory site in the extracellular vestibule.

PubMed: 40065647
DOI: 10.1111/bph.70011

Experimental method

X-RAY DIFFRACTION (3.2 Å)