9ESD

Holo TDO with a bound inhibitor

Summary for 9ESD

• Entry DOI: 10.2210/pdb9esd/pdb
• Descriptor: Tryptophan 2,3-dioxygenase, PROTOPORPHYRIN IX CONTAINING FE, (1~{R})-1-cyclohexyl-2-[(5~{S})-5~{H}-imidazo[1,5-b]isoindol-5-yl]ethanol, ... (4 entities in total)
• Functional Keywords: inhibitor, heme, oxidoreductase
• Biological source: Drosophila melanogaster (fruit fly)
• Total number of polymer chains: 4
• Total formula weight: 176814.14

Authors

Wicki, M.,Mac Sweeney, A. (deposition date: 2024-03-26, release date: 2025-03-05)

• Primary citation: Cren, S.,Lotz, C.,Mac Sweeney, A.,Lange, R.,Kimmerlin, T.; SAR and cellular potency optimization of novel heme-binding IDO1 inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.103 Å)