9ESD

Holo TDO with a bound inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
A	0006569	biological_process	L-tryptophan catabolic process
A	0006727	biological_process	ommochrome biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0019441	biological_process	L-tryptophan catabolic process to kynurenine
A	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
A	0020037	molecular_function	heme binding
A	0046872	molecular_function	metal ion binding
A	0048072	biological_process	compound eye pigmentation
A	0051213	molecular_function	dioxygenase activity
A	0051289	biological_process	protein homotetramerization
A	0070189	biological_process	kynurenine metabolic process
B	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
B	0006569	biological_process	L-tryptophan catabolic process
B	0006727	biological_process	ommochrome biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0019441	biological_process	L-tryptophan catabolic process to kynurenine
B	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
B	0020037	molecular_function	heme binding
B	0046872	molecular_function	metal ion binding
B	0048072	biological_process	compound eye pigmentation
B	0051213	molecular_function	dioxygenase activity
B	0051289	biological_process	protein homotetramerization
B	0070189	biological_process	kynurenine metabolic process
C	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
C	0006569	biological_process	L-tryptophan catabolic process
C	0006727	biological_process	ommochrome biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0019441	biological_process	L-tryptophan catabolic process to kynurenine
C	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
C	0020037	molecular_function	heme binding
C	0046872	molecular_function	metal ion binding
C	0048072	biological_process	compound eye pigmentation
C	0051213	molecular_function	dioxygenase activity
C	0051289	biological_process	protein homotetramerization
C	0070189	biological_process	kynurenine metabolic process
D	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
D	0006569	biological_process	L-tryptophan catabolic process
D	0006727	biological_process	ommochrome biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0019441	biological_process	L-tryptophan catabolic process to kynurenine
D	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding
D	0048072	biological_process	compound eye pigmentation
D	0051213	molecular_function	dioxygenase activity
D	0051289	biological_process	protein homotetramerization
D	0070189	biological_process	kynurenine metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03020

Chain	Residue	Details
A	PHE57
D	PHE57
D	ARG128
D	THR327
A	ARG128
A	THR327
B	PHE57
B	ARG128
B	THR327
C	PHE57
C	ARG128
C	THR327

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:23333332, ECO:0007744|PDB:4HKA

Chain	Residue	Details
A	HIS312
B	HIS312
C	HIS312
D	HIS312

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