9EOY

Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CaMKII alpha hub bound to PIPA

This is a non-PDB format compatible entry.

Summary for 9EOY

• Entry DOI: 10.2210/pdb9eoy/pdb
• Descriptor: Calcium/calmodulin-dependent protein kinase type II subunit alpha, ACETATE ION, 2-[6-(4-chlorophenyl)imidazo[1,2-b]pyridazin-2-yl]ethanoic acid, ... (5 entities in total)
• Functional Keywords: camkii hub, oligomer, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 7
• Total formula weight: 109984.94

Authors

Narayanan, D.,Larsen, A.S.G.,Solbak, S.M.O.,Wellendorph, P.,Gee, C.L.,Kastrup, J.S. (deposition date: 2024-03-15, release date: 2024-09-25)

• Primary citation: Narayanan, D.,Larsen, A.S.G.,Gauger, S.J.,Adafia, R.,Hammershoi, R.B.,Hamborg, L.,Bruus-Jensen, J.,Griem-Krey, N.,Gee, C.L.,Frolund, B.,Stratton, M.M.,Kuriyan, J.,Kastrup, J.S.,Langkilde, A.E.,Wellendorph, P.,Solbak, S.M.O.; Ligand-induced CaMKII alpha hub Trp403 flip, hub domain stacking, and modulation of kinase activity.; Protein Sci., 33:e5152-e5152, 2024; PubMed: 39275999; DOI: 10.1002/pro.5152

Experimental method

X-RAY DIFFRACTION (2.1 Å)