9EK5

TRIM21 PrySpry domain bound to an enhanced PRLX-93936 analog

This is a non-PDB format compatible entry.

Summary for 9EK5

• Entry DOI: 10.2210/pdb9ek5/pdb
• Descriptor: E3 ubiquitin-protein ligase TRIM21, (3P)-3-(4-chloro-2-ethoxyphenyl)-6-fluoro-2-[(piperazin-1-yl)methyl]quinazolin-4(3H)-one (3 entities in total)
• Functional Keywords: trim21, ubiquitin, ubiquitin ligase, small molecule, protein degradation, innate immunity, cancer, therapeutics, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 20922.86

Authors

Hinshaw, S.M.,Corsello, S.M.,Yuan, L.,Lu, J.,Martinez, M.,Gray, N.S. (deposition date: 2024-11-30, release date: 2025-08-27)

• Primary citation: Hinshaw, S.M.,Corsello, S.M.,Yuan, L.,Lu, J.,Martinez, M.,Gray, N.S.; TRIM21 PrySpry domain bound to an enhanced PRLX-93936 analog; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)