9EIK

Crystal structure of N-SH2 domain of SHP2 with T42A mutation bound to GAB1 tyrosine phosphorylated peptide (624-633) QVEpYLDLDLD

Summary for 9EIK

• Entry DOI: 10.2210/pdb9eik/pdb
• Related: 9EH9 9EHA 9EHD 9EIC
• Descriptor: Isoform 1 of Tyrosine-protein phosphatase non-receptor type 11, Phosphorylated peptide from GRB2-associated-binding protein 1 (3 entities in total)
• Functional Keywords: shp2, phosphatase, sh2, allostery, phosphotyrosine, activation, gab1, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 13479.90

Authors

Padua, R.A.P.,Glaser, A.,Ojoawo, A.,Kern, D. (deposition date: 2024-11-26, release date: 2026-01-07)

• Primary citation: Padua, R.A.P.,Glaser, A.,Ojoawo, A.,Kern, D.; Crystal structure of N-SH2 domain of SHP2 with T42A mutation bound to GAB1 tyrosine phosphorylated peptide (624-633) QVEpYLDLDLD; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.25 Å)