9EIK
Crystal structure of N-SH2 domain of SHP2 with T42A mutation bound to GAB1 tyrosine phosphorylated peptide (624-633) QVEpYLDLDLD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 1 of Tyrosine-protein phosphatase non-receptor type 11 | polymer | 109 | 12177.6 | 1 | UniProt (Q06124) Pfam (PF00017) | Homo sapiens (human) | Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,SHP-2,Shp2,SH-PTP3 |
| 2 | B (B) | Phosphorylated peptide from GRB2-associated-binding protein 1 | polymer | 10 | 1302.3 | 1 | UniProt (Q13480) | Homo sapiens | GRB2-associated binder 1,Growth factor receptor bound protein 2-associated protein 1 |
| 3 | C, D (A, B) | water | water | 18.0 | 111 | Chemie (HOH) |
Sequence modifications
A: 1 - 106 (UniProt: Q06124)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ala 42 | Thr 42 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 13479.9 | |
| All* | Total formula weight | 13479.9 |
