9EHO

Octopus ribosome, hybrid 80S

This is a non-PDB format compatible entry.

Summary for 9EHO

• Entry DOI: 10.2210/pdb9eho/pdb
• EMDB information: 48061
• Descriptor: 28S rRNA, Large ribosomal subunit protein uL15, 60S ribosomal protein L32, ... (83 entities in total)
• Functional Keywords: octopus ribosone, ribosome
• Biological source: Octopus; More
• Total number of polymer chains: 80
• Total formula weight: 4287248.79

Authors

Gao, J.,Yip, M.C.J.,Han, R.,Grearson, A.,Shao, S.,Lee, A.S.Y. (deposition date: 2024-11-24, release date: 2026-07-22)

Primary citation

Mitra, R.,Han, R.,Scott, T.J.,Grearson, A.G.,Willi, J.A.,Liu, C.G.,Kim, H.,Jewett, M.C.,Bellono, N.W.,Lee, A.S.
Evolution of a core ribosomal innovation in octopus.
Biorxiv, 2026

PubMed Abstract: Much of biology focuses on how genetic changes mediate new functions, but less attention is given to adaptations in other steps of the central dogma. Octopuses exhibit complex nervous systems and sophisticated behaviors that rival vertebrates, but via an entirely divergent evolutionary history. Here, we serendipitously discovered that octopus ribosomes contain a structural break in the core ribosomal RNA that is unique among all animals. This break site enhances translation fidelity to reduce miscoding and subsequent protein aggregation, even when engineered into evolutionarily distant bacterial ribosomes. Furthermore, high fidelity translation by octopus ribosomes supports proteomic stability during extensive RNA editing observed in cephalopods, suggesting synergy between distinct non-canonical modes of gene regulation. This adaptation emerged in recently derived octopuses with expanded nervous systems, thereby revealing a mechanism that could broadly support the evolution of novel organismal traits.

PubMed: 42395388
DOI: 10.64898/2026.06.25.734654

Experimental method

ELECTRON MICROSCOPY (3.1 Å)