9DAW

STING oligomer bound to cGAMP, C53 and PI(3,5)P2

This is a non-PDB format compatible entry.

Summary for 9DAW

• Entry DOI: 10.2210/pdb9daw/pdb
• Related: 9DAN 9DAT 9DAV
• EMDB information: 46700
• Descriptor: Stimulator of interferon genes protein, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl di[(9Z)-octadec-9-enoate], CHOLESTEROL HEMISUCCINATE, ... (5 entities in total)
• Functional Keywords: sting, oligomer, pi(3, 5)p2, signaling protein, signaling protein-activator complex, signaling protein/activator
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 163563.75

Authors

Li, J.,Zhang, X.,Bai, X. (deposition date: 2024-08-22, release date: 2025-12-17, Last modification date: 2026-02-04)

• Primary citation: Li, J.,Tan, J.X.,Chen, Z.J.,Zhang, X.,Bai, X.; Regulation of STING activation by phosphoinositide and cholesterol; Nature, 2026; DOI: 10.1038/s41586-025-10076-0

Experimental method

ELECTRON MICROSCOPY (2.9 Å)