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9DAW

STING oligomer bound to cGAMP, C53 and PI(3,5)P2

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Stimulator of interferon genes proteinpolymer35439553.44UniProt (Q86WV6)
Pfam (PF15009)
Homo sapiens (human)hSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,hMITA,Transmembrane protein 173
2E, J
(A, C)
(2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl di[(9Z)-octadec-9-enoate]non-polymer1023.12Chemie (A1BBH)
3F, K
(A, C)
CHOLESTEROL HEMISUCCINATEnon-polymer486.72Chemie (Y01)
4G, I
(B, C)
cGAMPnon-polymer674.42Chemie (1SY)
5H, L
(B, D)
1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamidenon-polymer490.92Chemie (9IM)
Sequence modifications
A, B, C, D: 1 - 344 (UniProt: Q86WV6)
PDBExternal DatabaseDetails
Arg 232His 232conflict
Thr 345-expression tag
Ser 346-expression tag
Ser 347-expression tag
Gly 348-expression tag
Leu 349-expression tag
Glu 350-expression tag
Val 351-expression tag
Leu 352-expression tag
Phe 353-expression tag
Gln 354-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight158213.6
Non-Polymers*Number of molecules8
Total formula weight5350.2
All*Total formula weight163563.8
*Water molecules are not included.

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PDB entries from 2025-12-24

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