9CYR

Crystal structure of D245G mutant human PTP1B (PTPN1) at room temperature (298 K)

Summary for 9CYR

Entry DOI	10.2210/pdb9cyr/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, BETA-MERCAPTOETHANOL, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	ptp1b, phosphatase, allostery, ptp, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	37410.04
Authors	Ebrahim, A.,Perdikari, A.,Woods, V.A.,Lawler, K.,Bounds, R.,Singh, N.I.,Mehlman, T.,Riley, B.T.,Sharma, S.,Morris, J.W.,Keogh, J.M.,Henning, E.,Smith, M.,Farooqi, I.S.,Keedy, D.A. (deposition date: 2024-08-02, release date: 2024-08-21)
Primary citation	Perdikari, A.,Woods, V.,Ebrahim, A.,Lawler, K.,Bounds, R.,Singh, N.,Mehlman, T.,Riley, B.,Sharma, S.,Morris, J.,Keogh, J.,Henning, E.,Smith, M.,Farooqi, I.,Keedy, D. Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy Biorxiv, 2024 Cited by DOI: 10.1101/2024.08.05.603709 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation