9CSY

SARS-CoV-2 papain-like protease (PLpro) bound to PF-07957472

This is a non-PDB format compatible entry.

Summary for 9CSY

• Entry DOI: 10.2210/pdb9csy/pdb
• Descriptor: Papain-like protease, 2-methyl-5-(4-methylpiperazin-1-yl)-N-{1-[(2P)-2-(1-methyl-1H-pyrazol-4-yl)quinolin-4-yl]cyclopropyl}benzamide, trifluoroacetic acid, ... (5 entities in total)
• Functional Keywords: papain-like protease, plpro, sars-cov-2 plpro, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 3
• Total formula weight: 109469.74

Authors

Mashalidis, E.H.,Chang, J.S.,Wu, H.,Garnsey, M. (deposition date: 2024-07-24, release date: 2024-10-02)

• Primary citation: Garnsey, M.R.,Robinson, M.C.,Nguyen, L.T.,Cardin, R.,Tillotson, J.,Mashalidis, E.,Yu, A.,Aschenbrenner, L.,Balesano, A.,Behzadi, A.,Boras, B.,Chang, J.S.,Eng, H.,Ephron, A.,Foley, T.,Ford, K.K.,Frick, J.M.,Gibson, S.,Hao, L.,Hurst, B.,Kalgutkar, A.S.,Korczynska, M.,Lengyel-Zhand, Z.,Gao, L.,Meredith, H.R.,Patel, N.C.,Polivkova, J.,Rai, D.,Rose, C.R.,Rothan, H.,Sakata, S.K.,Vargo, T.R.,Qi, W.,Wu, H.,Liu, Y.,Yurgelonis, I.,Zhang, J.,Zhu, Y.,Zhang, L.,Lee, A.A.; Discovery of SARS-CoV-2 papain-like protease (PL pro ) inhibitors with efficacy in a murine infection model.; Sci Adv, 10:eado4288-eado4288, 2024; PubMed: 39213347; DOI: 10.1126/sciadv.ado4288

Experimental method

X-RAY DIFFRACTION (2.595 Å)