9CSY
SARS-CoV-2 papain-like protease (PLpro) bound to PF-07957472
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Papain-like protease | polymer | 318 | 35927.7 | 3 | UniProt (P0DTC1) Pfam (PF08715) | Severe acute respiratory syndrome coronavirus 2 | Non-structural protein 3, nsp3, PL2-PRO, Papain-like proteinase, PL-PRO |
| 2 | D, G, I (A, B, C) | 2-methyl-5-(4-methylpiperazin-1-yl)-N-{1-[(2P)-2-(1-methyl-1H-pyrazol-4-yl)quinolin-4-yl]cyclopropyl}benzamide | non-polymer | 480.6 | 3 | Chemie (A1AZ1) | |||
| 3 | E (A) | trifluoroacetic acid | non-polymer | 114.0 | 1 | Chemie (TFA) | |||
| 4 | F, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | J, K, L (A, B, C) | water | water | 18.0 | 136 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 315 (UniProt: P0DTC1)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Ser 111 | Cys 1674 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 107783.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1686.7 | |
| All* | Total formula weight | 109469.7 |
