9CSD

The Ectodomains of SPRING and S1P with the inhibitor PF-429242

This is a non-PDB format compatible entry.

Summary for 9CSD

• Entry DOI: 10.2210/pdb9csd/pdb
• EMDB information: 45892
• Descriptor: Membrane-bound transcription factor site-1 protease, SREBP regulating gene protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: protease, complex, inhibitor, membrane protein, membrane protein-inhibitor complex, membrane protein/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 139505.89

Authors

Kober, D.L. (deposition date: 2024-07-23, release date: 2025-04-23)

• Primary citation: Bullington, A.V.,Micallo, I.,Bajaj, B.,Kumar, P.,Schlamowitz, N.,Silva, A.,Hendrix, S.,Zelcer, N.,Kober, D.L.; Structural basis for substrate selectivity by site-one protease revealed by studies with a small-molecule inhibitor; Proc.Natl.Acad.Sci.USA, 2025

Experimental method

ELECTRON MICROSCOPY (2.4 Å)