9CR7

Structure of human SETD8 in complex with covalent inhibitor AM2928

Summary for 9CR7

• Entry DOI: 10.2210/pdb9cr7/pdb
• Descriptor: N-lysine methyltransferase KMT5A, N-(3-{[7-(2-aminoethoxy)-6-methoxy-2-(pyrrolidin-1-yl)quinazolin-4-yl]amino}propyl)prop-2-enamide, N-(3-{[7-(2-aminoethoxy)-6-methoxy-2-(pyrrolidin-1-yl)quinazolin-4-yl]amino}propyl)prop-2-ynamide, ... (4 entities in total)
• Functional Keywords: setd8, lysine methyltransferase, kmt, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 41344.29

Authors

Babault, N.,Park, K.S.,Jin, J. (deposition date: 2024-07-20, release date: 2025-07-30)

• Primary citation: Ma, A.,Babault, N.,Hong, W.,Dong, A.,Hong, Z.,Xin, C.,Park, K.S.,Brown, P.J.,Liu, J.,Vedadi, M.,Jin, J.; Structure-Activity relationship studies of SETD8 covalent inhibitors; To be published,

Experimental method

X-RAY DIFFRACTION (2.05 Å)