9CBM

Cryo-EM structure of dexmedetomidine-bound alpha-2A-adrenergic receptor in complex with heterotrimeric Gi-protein

Summary for 9CBM

• Entry DOI: 10.2210/pdb9cbm/pdb
• EMDB information: 45426
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
• Functional Keywords: gpcr adrenergic receptor, signaling protein
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 4
• Total formula weight: 143194.03

Authors

Lou, J.S.,Su, M.,Wang, J.,Do, H.N.,Miao, Y.,Huang, X.Y. (deposition date: 2024-06-19, release date: 2024-09-11)

• Primary citation: Lou, J.S.,Su, M.,Wang, J.,Do, H.N.,Miao, Y.,Huang, X.Y.; Distinct binding conformations of epinephrine with alpha- and beta-adrenergic receptors.; Exp.Mol.Med., 2024; PubMed: 39218975; DOI: 10.1038/s12276-024-01296-x

Experimental method

ELECTRON MICROSCOPY (3.2 Å)