9C6W

Crystal Structure of a single chain trimer composed of HLA-B*39:06 Y84C variant, beta-2microglobulin, and NRVMLPKAA peptide from NLRP2 (2 molecules/asymmetric unit)

9C6W の概要

• エントリーDOI: 10.2210/pdb9c6w/pdb
• 関連するPDBエントリー: 9C6V 9C6X
• 分子名称: NACHT, LRR and PYD domains-containing protein 2,Beta-2-microglobulin,MHC class I antigen, SULFATE ION, 1,2-ETHANEDIOL, ... (8 entities in total)
• 機能のキーワード: hla class i histocompatibility antigen, b-39 alpha chain, beta-2-microglobulin, nlrp2, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 96946.77

構造登録者

Sharma, R.,Amdare, N.P.,Celikgil, A.,Garforth, S.J.,DiLorenzo, T.P.,Almo, S.C.,Ghosh, A. (登録日: 2024-06-09, 公開日: 2024-09-04, 最終更新日: 2024-10-02)

• 主引用文献: Sharma, R.,Amdare, N.P.,Ghosh, A.,Schloss, J.,Sidney, J.,Garforth, S.J.,Lopez, Y.,Celikgil, A.,Sette, A.,Almo, S.C.,DiLorenzo, T.P.; Structural and biochemical analysis of highly similar HLA-B allotypes differentially associated with type 1 diabetes.; J.Biol.Chem., 300:107702-107702, 2024; PubMed: 39173948; DOI: 10.1016/j.jbc.2024.107702

実験手法

X-RAY DIFFRACTION (1.7 Å)