9C6W
Crystal Structure of a single chain trimer composed of HLA-B*39:06 Y84C variant, beta-2microglobulin, and NRVMLPKAA peptide from NLRP2 (2 molecules/asymmetric unit)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NACHT, LRR and PYD domains-containing protein 2,Beta-2-microglobulin,MHC class I antigen | polymer | 419 | 46912.5 | 2 | UniProt (Q9NX02) UniProt (P61769) UniProt (I3ZN83) Pfam (PF07654) Pfam (PF00129) | Homo sapiens (human) | Nucleotide-binding site protein 1,PYRIN domain and NACHT domain-containing protein 1,PYRIN-containing APAF1-like protein 2,Major histocompatibility complex |
| 2 | AA, C, D, E, F... (B, A) | SULFATE ION | non-polymer | 96.1 | 15 | Chemie (SO4) | |||
| 3 | DA, EA, FA, GA, HA... (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 17 | Chemie (EDO) | |||
| 4 | R, S (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 5 | BA, CA (B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | MA (B) | 3,6,9,12,15-PENTAOXAHEPTADECANE | non-polymer | 250.3 | 1 | Chemie (P3G) | |||
| 7 | NA (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 8 | OA, PA (A, B) | water | water | 18.0 | 419 | Chemie (HOH) |
Sequence modifications
A, B: 323 - 331 (UniProt: Q9NX02)
A, B: 1002 - 1980 (UniProt: P61769)
A, B: 2002 - 2275 (UniProt: I3ZN83)
| PDB | External Database | Details |
|---|---|---|
| Gly 332 | - | linker |
| Cys 333 | - | linker |
| Gly 988 | - | linker |
| Ala 989 | - | linker |
| Ser 990 | - | linker |
| Gly 991 | - | linker |
| Gly 992 | - | linker |
| Gly 993 | - | linker |
| Gly 994 | - | linker |
| Ser 995 | - | linker |
| Gly 996 | - | linker |
| Gly 997 | - | linker |
| Gly 998 | - | linker |
| Gly 999 | - | linker |
| Ser 1000 | - | linker |
| Met 1001 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 1981 | - | linker |
| Gly 1982 | - | linker |
| Gly 1983 | - | linker |
| Gly 1984 | - | linker |
| Ser 1985 | - | linker |
| Gly 1986 | - | linker |
| Gly 1987 | - | linker |
| Gly 1988 | - | linker |
| Gly 1989 | - | linker |
| Ser 1990 | - | linker |
| Gly 1991 | - | linker |
| Gly 1992 | - | linker |
| Gly 1993 | - | linker |
| Gly 1994 | - | linker |
| Ser 1995 | - | linker |
| Gly 1996 | - | linker |
| Gly 1997 | - | linker |
| Gly 1998 | - | linker |
| Gly 1999 | - | linker |
| Ser 2000 | - | linker |
| Gly 2001 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Cys 2084 | Tyr 108 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 93825.1 | |
| Non-Polymers* | Number of molecules | 38 |
| Total formula weight | 3121.7 | |
| All* | Total formula weight | 96946.8 |
