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9BQE

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with (6'-hydroxy-1'-(4-(2-(1-propylpyrrolidin-3-yl)ethoxy)phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone

Summary for 9BQE
Entry DOI10.2210/pdb9bqe/pdb
DescriptorEstrogen receptor, [(1'R)-6'-hydroxy-1'-(4-{[(3R)-1-propylpyrrolidin-3-yl]methoxy}phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl](phenyl)methanone (3 entities in total)
Functional Keywordsestrogen receptor, breast cancer, alpha helical bundle, transcription
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight61025.26
Authors
Young, K.Y.,Fanning, S.W. (deposition date: 2024-05-09, release date: 2024-06-19)
Primary citationFanning, S.W.
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with (6'-hydroxy-1'-(4-(2-(1-propylpyrrolidin-3-yl)ethoxy)phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.98 Å)
Structure validation

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PDB entries from 2024-11-13

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