9BQE
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with (6'-hydroxy-1'-(4-(2-(1-propylpyrrolidin-3-yl)ethoxy)phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Estrogen receptor | polymer | 262 | 30016.0 | 2 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
2 | A, B | [(1'R)-6'-hydroxy-1'-(4-{[(3R)-1-propylpyrrolidin-3-yl]methoxy}phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl](phenyl)methanone | non-polymer | 496.6 | 2 | Chemie (TV3) | |||
3 | water | water | 18.0 | 121 | Chemie (HOH) |
Sequence modifications
A, B: 305 - 554 (UniProt: P03372)
PDB | External Database | Details |
---|---|---|
His 293 | - | expression tag |
His 294 | - | expression tag |
His 295 | - | expression tag |
His 296 | - | expression tag |
His 297 | - | expression tag |
His 298 | - | expression tag |
Glu 299 | - | expression tag |
Asn 300 | - | expression tag |
Leu 301 | - | expression tag |
Tyr 302 | - | expression tag |
Phe 303 | - | expression tag |
Gln 304 | - | expression tag |
Ser 381 | Cys 381 | engineered mutation |
Ser 417 | Cys 417 | engineered mutation |
Ser 530 | Cys 530 | engineered mutation |
Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 60032.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 993.3 | |
All* | Total formula weight | 61025.3 |