9BOX

Room-temperature X-ray structure of human mitochondrial serine hydroxymethyltransferase (hSHMT2) with PLP-glycine external aldimine and 5-formyltetrahydrofolate (folinic acid)

This is a non-PDB format compatible entry.

Summary for 9BOX

• Entry DOI: 10.2210/pdb9box/pdb
• Descriptor: Serine hydroxymethyltransferase, mitochondrial, (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)glycine, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, ... (4 entities in total)
• Functional Keywords: pyridoxal 5'-phosphate, plp, fold type 1, one carbon metabolism, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 208428.34

Authors

Drago, V.N.,Kovalevsky, A. (deposition date: 2024-05-06, release date: 2024-08-28)

• Primary citation: Drago, V.N.,Phillips, R.S.,Kovalevsky, A.; Universality of critical active site glutamate as an acid-base catalyst in serine hydroxymethyltransferase function.; Chem Sci, 15:12827-12844, 2024; PubMed: 39148791; DOI: 10.1039/d4sc03187c

Experimental method

X-RAY DIFFRACTION (2.1 Å)