9BOX

Room-temperature X-ray structure of human mitochondrial serine hydroxymethyltransferase (hSHMT2) with PLP-glycine external aldimine and 5-formyltetrahydrofolate (folinic acid)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002082	biological_process	regulation of oxidative phosphorylation
A	0003682	molecular_function	chromatin binding
A	0004372	molecular_function	glycine hydroxymethyltransferase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005759	cellular_component	mitochondrial matrix
A	0006417	biological_process	regulation of translation
A	0006544	biological_process	glycine metabolic process
A	0006545	biological_process	glycine biosynthetic process
A	0006563	biological_process	L-serine metabolic process
A	0006564	biological_process	L-serine biosynthetic process
A	0006730	biological_process	one-carbon metabolic process
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008732	molecular_function	L-allo-threonine aldolase activity
A	0015630	cellular_component	microtubule cytoskeleton
A	0015943	biological_process	formate biosynthetic process
A	0016020	cellular_component	membrane
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0019264	biological_process	glycine biosynthetic process from serine
A	0030170	molecular_function	pyridoxal phosphate binding
A	0034340	biological_process	response to type I interferon
A	0035999	biological_process	tetrahydrofolate interconversion
A	0042645	cellular_component	mitochondrial nucleoid
A	0042802	molecular_function	identical protein binding
A	0046653	biological_process	tetrahydrofolate metabolic process
A	0051262	biological_process	protein tetramerization
A	0051289	biological_process	protein homotetramerization
A	0070013	cellular_component	intracellular organelle lumen
A	0070062	cellular_component	extracellular exosome
A	0070129	biological_process	regulation of mitochondrial translation
A	0070536	biological_process	protein K63-linked deubiquitination
A	0070552	cellular_component	BRISC complex
A	1903715	biological_process	regulation of aerobic respiration
B	0002082	biological_process	regulation of oxidative phosphorylation
B	0003682	molecular_function	chromatin binding
B	0004372	molecular_function	glycine hydroxymethyltransferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005759	cellular_component	mitochondrial matrix
B	0006417	biological_process	regulation of translation
B	0006544	biological_process	glycine metabolic process
B	0006545	biological_process	glycine biosynthetic process
B	0006563	biological_process	L-serine metabolic process
B	0006564	biological_process	L-serine biosynthetic process
B	0006730	biological_process	one-carbon metabolic process
B	0008284	biological_process	positive regulation of cell population proliferation
B	0008732	molecular_function	L-allo-threonine aldolase activity
B	0015630	cellular_component	microtubule cytoskeleton
B	0015943	biological_process	formate biosynthetic process
B	0016020	cellular_component	membrane
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0019264	biological_process	glycine biosynthetic process from serine
B	0030170	molecular_function	pyridoxal phosphate binding
B	0034340	biological_process	response to type I interferon
B	0035999	biological_process	tetrahydrofolate interconversion
B	0042645	cellular_component	mitochondrial nucleoid
B	0042802	molecular_function	identical protein binding
B	0046653	biological_process	tetrahydrofolate metabolic process
B	0051262	biological_process	protein tetramerization
B	0051289	biological_process	protein homotetramerization
B	0070013	cellular_component	intracellular organelle lumen
B	0070062	cellular_component	extracellular exosome
B	0070129	biological_process	regulation of mitochondrial translation
B	0070536	biological_process	protein K63-linked deubiquitination
B	0070552	cellular_component	BRISC complex
B	1903715	biological_process	regulation of aerobic respiration
C	0002082	biological_process	regulation of oxidative phosphorylation
C	0003682	molecular_function	chromatin binding
C	0004372	molecular_function	glycine hydroxymethyltransferase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005759	cellular_component	mitochondrial matrix
C	0006417	biological_process	regulation of translation
C	0006544	biological_process	glycine metabolic process
C	0006545	biological_process	glycine biosynthetic process
C	0006563	biological_process	L-serine metabolic process
C	0006564	biological_process	L-serine biosynthetic process
C	0006730	biological_process	one-carbon metabolic process
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008732	molecular_function	L-allo-threonine aldolase activity
C	0015630	cellular_component	microtubule cytoskeleton
C	0015943	biological_process	formate biosynthetic process
C	0016020	cellular_component	membrane
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0019264	biological_process	glycine biosynthetic process from serine
C	0030170	molecular_function	pyridoxal phosphate binding
C	0034340	biological_process	response to type I interferon
C	0035999	biological_process	tetrahydrofolate interconversion
C	0042645	cellular_component	mitochondrial nucleoid
C	0042802	molecular_function	identical protein binding
C	0046653	biological_process	tetrahydrofolate metabolic process
C	0051262	biological_process	protein tetramerization
C	0051289	biological_process	protein homotetramerization
C	0070013	cellular_component	intracellular organelle lumen
C	0070062	cellular_component	extracellular exosome
C	0070129	biological_process	regulation of mitochondrial translation
C	0070536	biological_process	protein K63-linked deubiquitination
C	0070552	cellular_component	BRISC complex
C	1903715	biological_process	regulation of aerobic respiration
D	0002082	biological_process	regulation of oxidative phosphorylation
D	0003682	molecular_function	chromatin binding
D	0004372	molecular_function	glycine hydroxymethyltransferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005759	cellular_component	mitochondrial matrix
D	0006417	biological_process	regulation of translation
D	0006544	biological_process	glycine metabolic process
D	0006545	biological_process	glycine biosynthetic process
D	0006563	biological_process	L-serine metabolic process
D	0006564	biological_process	L-serine biosynthetic process
D	0006730	biological_process	one-carbon metabolic process
D	0008284	biological_process	positive regulation of cell population proliferation
D	0008732	molecular_function	L-allo-threonine aldolase activity
D	0015630	cellular_component	microtubule cytoskeleton
D	0015943	biological_process	formate biosynthetic process
D	0016020	cellular_component	membrane
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0019264	biological_process	glycine biosynthetic process from serine
D	0030170	molecular_function	pyridoxal phosphate binding
D	0034340	biological_process	response to type I interferon
D	0035999	biological_process	tetrahydrofolate interconversion
D	0042645	cellular_component	mitochondrial nucleoid
D	0042802	molecular_function	identical protein binding
D	0046653	biological_process	tetrahydrofolate metabolic process
D	0051262	biological_process	protein tetramerization
D	0051289	biological_process	protein homotetramerization
D	0070013	cellular_component	intracellular organelle lumen
D	0070062	cellular_component	extracellular exosome
D	0070129	biological_process	regulation of mitochondrial translation
D	0070536	biological_process	protein K63-linked deubiquitination
D	0070552	cellular_component	BRISC complex
D	1903715	biological_process	regulation of aerobic respiration

Functional Information from PROSITE/UniProt

site_id	PS00096
Number of Residues	17
Details	SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. DIvTTTTHKTLrGARSG

Chain	Residue	Details
A	ASP272-GLY288

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"29180469","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---