9BJI

Cryo-EM structure of apo NVL

Summary for 9BJI

• Entry DOI: 10.2210/pdb9bji/pdb
• Related: 9BJJ
• EMDB information: 44633 44634
• Descriptor: Substrate mimic, Nuclear valosin-containing protein-like, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: ribosome biogenesis, aaa+ atpase, translocase
• Biological source: Escherichia coli BL21(DE3); More
• Total number of polymer chains: 7
• Total formula weight: 579184.56

Authors

Cruz, V.E.,Erzberger, J.P. (deposition date: 2024-04-25, release date: 2026-01-21)

• Primary citation: Guo, H.H.,Tao, Y.,Cruz, V.E.,Fang, M.,Khivansara, V.,Xie, S.,Leach, A.,Rivera-Cancel, G.,Barrows, N.,Williams, N.,Aurora, A.,Erzberger, J.P.,De Brabander, J.K.,Nijhawan, D.; Dibenzothiazepinones are bioavailable inhibitors of NVL and cause p53-dependent apoptosis in cancer by blocking 60S ribosome assembly; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.83 Å)