9BJI

Cryo-EM structure of apo NVL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000176	cellular_component	nuclear exosome (RNase complex)
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005697	cellular_component	telomerase holoenzyme complex
A	0005730	cellular_component	nucleolus
A	0006364	biological_process	rRNA processing
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0032092	biological_process	positive regulation of protein binding
A	0032206	biological_process	positive regulation of telomere maintenance
A	0042254	biological_process	ribosome biogenesis
A	0042273	biological_process	ribosomal large subunit biogenesis
A	0044877	molecular_function	protein-containing complex binding
A	1904749	biological_process	regulation of protein localization to nucleolus
A	1905323	biological_process	telomerase holoenzyme complex assembly
A	1990275	molecular_function	preribosome binding
B	0000176	cellular_component	nuclear exosome (RNase complex)
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005697	cellular_component	telomerase holoenzyme complex
B	0005730	cellular_component	nucleolus
B	0006364	biological_process	rRNA processing
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0032092	biological_process	positive regulation of protein binding
B	0032206	biological_process	positive regulation of telomere maintenance
B	0042254	biological_process	ribosome biogenesis
B	0042273	biological_process	ribosomal large subunit biogenesis
B	0044877	molecular_function	protein-containing complex binding
B	1904749	biological_process	regulation of protein localization to nucleolus
B	1905323	biological_process	telomerase holoenzyme complex assembly
B	1990275	molecular_function	preribosome binding
C	0000176	cellular_component	nuclear exosome (RNase complex)
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005697	cellular_component	telomerase holoenzyme complex
C	0005730	cellular_component	nucleolus
C	0006364	biological_process	rRNA processing
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0032092	biological_process	positive regulation of protein binding
C	0032206	biological_process	positive regulation of telomere maintenance
C	0042254	biological_process	ribosome biogenesis
C	0042273	biological_process	ribosomal large subunit biogenesis
C	0044877	molecular_function	protein-containing complex binding
C	1904749	biological_process	regulation of protein localization to nucleolus
C	1905323	biological_process	telomerase holoenzyme complex assembly
C	1990275	molecular_function	preribosome binding
D	0000176	cellular_component	nuclear exosome (RNase complex)
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005697	cellular_component	telomerase holoenzyme complex
D	0005730	cellular_component	nucleolus
D	0006364	biological_process	rRNA processing
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0032092	biological_process	positive regulation of protein binding
D	0032206	biological_process	positive regulation of telomere maintenance
D	0042254	biological_process	ribosome biogenesis
D	0042273	biological_process	ribosomal large subunit biogenesis
D	0044877	molecular_function	protein-containing complex binding
D	1904749	biological_process	regulation of protein localization to nucleolus
D	1905323	biological_process	telomerase holoenzyme complex assembly
D	1990275	molecular_function	preribosome binding
E	0000176	cellular_component	nuclear exosome (RNase complex)
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005697	cellular_component	telomerase holoenzyme complex
E	0005730	cellular_component	nucleolus
E	0006364	biological_process	rRNA processing
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0032092	biological_process	positive regulation of protein binding
E	0032206	biological_process	positive regulation of telomere maintenance
E	0042254	biological_process	ribosome biogenesis
E	0042273	biological_process	ribosomal large subunit biogenesis
E	0044877	molecular_function	protein-containing complex binding
E	1904749	biological_process	regulation of protein localization to nucleolus
E	1905323	biological_process	telomerase holoenzyme complex assembly
E	1990275	molecular_function	preribosome binding
F	0000176	cellular_component	nuclear exosome (RNase complex)
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005697	cellular_component	telomerase holoenzyme complex
F	0005730	cellular_component	nucleolus
F	0006364	biological_process	rRNA processing
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0032092	biological_process	positive regulation of protein binding
F	0032206	biological_process	positive regulation of telomere maintenance
F	0042254	biological_process	ribosome biogenesis
F	0042273	biological_process	ribosomal large subunit biogenesis
F	0044877	molecular_function	protein-containing complex binding
F	1904749	biological_process	regulation of protein localization to nucleolus
F	1905323	biological_process	telomerase holoenzyme complex assembly
F	1990275	molecular_function	preribosome binding

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. VlVIgATNrpdsLDpALr.R

Chain	Residue	Details
A	VAL404-ARG422
A	VAL718-ARG736

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1035
Details	Region: {"description":"Interaction with WDR74","evidences":[{"source":"PubMed","id":"28416111","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	84
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22226966","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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