9B37

Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to one concanavalin A dimer. Composite map.

Summary for 9B37

• Entry DOI: 10.2210/pdb9b37/pdb
• EMDB information: 44130
• Descriptor: Glutamate receptor ionotropic, kainate 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, ... (17 entities in total)
• Functional Keywords: kainate receptor, gluk2, positive allosteric modulator, bpam344, open, concanavalin a, cona, glutamate, membrane protein
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 497410.32

Authors

Nadezhdin, K.D.,Gangwar, S.P.,Sobolevsky, A.I. (deposition date: 2024-03-18, release date: 2024-05-22, Last modification date: 2024-06-26)

• Primary citation: Gangwar, S.P.,Yelshanskaya, M.V.,Nadezhdin, K.D.,Yen, L.Y.,Newton, T.P.,Aktolun, M.,Kurnikova, M.G.,Sobolevsky, A.I.; Kainate receptor channel opening and gating mechanism.; Nature, 630:762-768, 2024; PubMed: 38778115; DOI: 10.1038/s41586-024-07475-0

Experimental method

ELECTRON MICROSCOPY (6.66 Å)