9B37
Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to one concanavalin A dimer. Composite map.
9B37 の概要
エントリーDOI | 10.2210/pdb9b37/pdb |
EMDBエントリー | 44130 |
分子名称 | Glutamate receptor ionotropic, kainate 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, ... (17 entities in total) |
機能のキーワード | kainate receptor, gluk2, positive allosteric modulator, bpam344, open, concanavalin a, cona, glutamate, membrane protein |
由来する生物種 | Rattus norvegicus (Norway rat) 詳細 |
タンパク質・核酸の鎖数 | 6 |
化学式量合計 | 497410.32 |
構造登録者 | Nadezhdin, K.D.,Gangwar, S.P.,Sobolevsky, A.I. (登録日: 2024-03-18, 公開日: 2024-05-22, 最終更新日: 2024-06-26) |
主引用文献 | Gangwar, S.P.,Yelshanskaya, M.V.,Nadezhdin, K.D.,Yen, L.Y.,Newton, T.P.,Aktolun, M.,Kurnikova, M.G.,Sobolevsky, A.I. Kainate receptor channel opening and gating mechanism. Nature, 630:762-768, 2024 Cited by PubMed: 38778115DOI: 10.1038/s41586-024-07475-0 主引用文献が同じPDBエントリー |
実験手法 | ELECTRON MICROSCOPY (6.66 Å) |
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